Jabra Talk

If you're looking to buy your first Bluetooth headset, you're probably not looking for a pricey, top-of-the-line model with a ton of features you never even knew existed. Chances are you're looking for something more like the $29.99 (list) Jabra Talk. It's easy to set up and use, and you can find it out there for well under its list price, which makes it about as much of an investment as a large pepperoni pizza. But let's make this clear: The Jabra Talk?isn't a great headset. The fit could be better, and noise cancellation is pretty poor. Still, if you're new to Bluetooth, it sounds pretty good and is a reasonably priced entry point.

Design, Fit, and Pairing
The Jabra Talk looks like your run-of-the-mill Bluetooth headset. It measures 0.95 by 2.1 by 0.65 inches (HWD) and weighs 0.35 ounces. It's made mostly of matte black plastic, with a silver plastic line that runs along the outer edge, and a chunky strip that separates the front of the headset's face from the button on the other side. Controls are sparse. There's a power switch on the inside of the headset, right next to the earpiece. Two hidden LED lights indicate Bluetooth connectivity and battery life. Volume control is located on the bottom of the headset, and is easy to toggle while you're on a call. A multifunction Call button is located right next to your ear, and can be used to answer and end calls, redial numbers, and trigger voice dialing.

The headset uses an in-ear design and comes with three different size silicone ear buds and two different plastic hooks. I'm not a fan of the hook, even though they do make the fit more secure. I wasn't thrilled with the fit of any of the ear buds, either, but I found the middle size the most comfortable to wear without needing to hook myself in. Luckily, because the headset is light, once I established the proper fit I practically forgot it was there.

The Talk is automatically set to pairing mode the first time you turn it on. For subsequent pairings, all you have to do is hold down the Call button for a few seconds until the Bluetooth indicator begins to flash. From there, simply follow the instructions on your device for a standard Bluetooth pairing procedure. For this review, I had no trouble pairing the Talk with an Apple iPhone 4S?and a Sony Xperia ZL.

Sound Quality, Noise Cancellation, and Conclusions
Once paired, you can initiate voice dialing by holding down the Call button for a couple of seconds. It will initiate whatever voice control you use, like Google Voice or Siri. I had no trouble making calls, asking Siri to play some music, or having Google Voice open up the calendar app. You can tap the Call button once to answer or end a call, and twice to redial the last number you were connected to.

Call quality is mixed. With the Talk in your ear, voices can sound a little digitized, with some fuzz around the edge, but overall volume goes loud and calls sound clear enough that you won't have trouble understanding anyone. But on the other end, calls made with the Talk have very low volume and sound a bit muffled. Even worse is that it sounds like there is next to no noise cancellation, so it's easy for your voice to get lost if you're calling from a noisy place. Calls made indoors were mostly fine, but this isn't the right headset for you if you plan to use it a lot while on the go.

The Jabra Talk doesn't have many additional features, but it supports A2DP, so you can use it to listen to streaming media like apps, audiobooks, music, and podcasts. The headset gets pretty loud, so volume isn't a problem, but for music, bass is basically nonexistent. Still, it sounds fine for podcasts, and most people don't use mono headsets for music anyway.

Range was fine; I was able to clear the standard 20 feet before sound started to break up. And battery life is okay, at 5 hours and 21 minutes. Jabra claims the headset can last up to eight days on standby.

The Jabra Talk doesn't have a ton of cool features or bar-setting performance. And if you plan to use it outdoors, its lousy noise cancellation means you should probably look for a different headset. But for just over $20, depending on where you buy it, I don't want to knock the Talk too hard. It's still a perfectly decent headset, especially if this is your first time using Bluetooth. It's actually a better choice than the similarly priced Samsung HM1800, since that headset lacks A2DP.

But if you're willing to spend a little more, the Plantronics M55?is our Editors' Choice for budget Bluetooth headsets. It costs nearly twice the price, but it has better call quality and noise cancellation, much longer battery life, and a sleeker design. The Plantronics Marque 2 M165?is another good option, while the Sony SBH20?gets you a unique clip-on design, along with excellent stereo sound quality through a pair of wired earbuds.

Source: http://feedproxy.google.com/~r/ziffdavis/pcmag/~3/a7ZR-FyjpVM/0,2817,2418224,00.asp

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Lawmakers: Syria chemical weapons could menace U.S.

WASHINGTON (AP) ? Syria's stockpile of chemical weapons could be a greater threat after that nation's president leaves power and could end up targeting Americans at home, lawmakers warned Sunday as they considered a U.S. response that stops short of sending military forces there.

U.S. officials last week declared that the Syrian government probably had used chemical weapons twice in March, newly provocative acts in the 2-year civil war that has killed more than 70,000 people and displaced hundreds of thousands more. The U.S. assessment followed similar conclusions from Britain, France, Israel and Qatar ? key allies eager for a more aggressive response to the Syrian conflict.

President Barack Obama has said Syria's likely action ? or the transfer of President Bashar Assad's stockpiles to terrorists ? would cross a "red line" that would compel the United States to act.

Lawmakers sought to remind viewers on Sunday news programs of Obama's declaration while discouraging a U.S. foothold on the ground there.

"The president has laid down the line, and it can't be a dotted line. It can't be anything other than a red line," said House Intelligence Committee Chairman Rep. Mike Rogers, R-Mich. "And more than just Syria, Iran is paying attention to this. North Korea is paying attention to this."

Added Sen. Saxby Chambliss, R-Ga.: "For America to sit on the sidelines and do nothing is a huge mistake."

Obama has insisted that any use of chemical weapons would change his thinking about the United States' role in Syria but said he didn't have enough information to order aggressive action.

"For the Syrian government to utilize chemical weapons on its people crosses a line that will change my calculus and how the United States approaches these issues," Obama said Friday.

But Rep. Jan Schakowsky, an Illinois Democrat, said Sunday the United States needs to consider those weapons. She said that when Assad leaves power, his opponents could have access to those weapons or they could fall into the hands of U.S. enemies.

"The day after Assad is the day that these chemical weapons could be at risk ... (and) we could be in bigger, even bigger trouble," she said.

Both sides of the civil war already accuse each other of using the chemical weapons.

The deadliest such alleged attack was in the Khan al-Assal village in the Aleppo province in March. The Syrian government called for the United Nations to investigate alleged chemical weapons use by rebels in the attack that killed 31 people.

Syria, however, has not allowed a team of experts into the country because it wants the investigation limited to the single Khan al-Assal incident, while U.N. Secretary-General Ban Ki-moon has urged "immediate and unfettered access" for an expanded investigation.

One of Obama's chief antagonists on Syria, Sen. John McCain, R- Ariz., said the United States should go to Syria as part of an international force to safeguard the chemical weapons. But McCain added that he is not advocating sending ground troops to the nation.

"The worst thing the United States could do right now is put boots on the ground on Syria. That would turn the people against us," McCain said.

His friend, Sen. Lindsey Graham, R-S.C., also said the United States could safeguard the weapons without a ground force. But he cautioned the weapons must be protected for fear that Americans could be targeted. Raising the specter of the lethal bomb at the finish line of the Boston Marathon, Graham said the next attack on U.S. soil could employ weapons that were once part of Assad's arsenal.

"Chemical weapons ? enough to kill millions of people ? are going to be compromised and fall into the wrong hands, and the next bomb that goes off in America may not have nails and glass in it," he said.

Rogers and Schakowsky spoke to ABC's "This Week." Chambliss and Graham were interviewed on CBS's "Face the Nation." McCain appeared on NBC's "Meet the Press."

___

Follow Philip Elliott on Twitter: https://twitter.com/Philip_Elliott

Source: http://news.yahoo.com/lawmakers-syria-chemical-weapons-could-menace-us-154735931.html

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PFT: EJ Manuel goes to Bills at No. 16, first QB taken

AP

Five trades occurred in Round One of the 2013 NFL Draft on Thursday. Here are the terms of those deals:

The Dolphins acquired the Raiders? first-round choice (No. 3 overall), with Oakland receiving Miami?s first- and second-round choices?(Nos. 12 and 42) in return. The Dolphins selected Oregon defensive end Dion Jordan with the No. 3 overall pick, with the Raiders taking D.J. Hayden 12th.

The Rams traded for the Bills? first- and third-round choices?(Nos. 8 and 71), with Buffalo getting St. Louis??first-, second-, third- and seventh-round choices?(Nos. 16, 46, 78, 222). With the No. 8 pick, the Rams drafted West Virginia wide receiver Tavon Austin. At No. 16, the Bills selected?Florida State quarterback E.J. Manuel.

The 49ers traded up with Dallas, acquiring the?Cowboys? first-round choice?(No. 18) for San Francisco?s first- and third-round choices (Nos. 31 and 74, the latter of which once belonged to Carolina). At No. 18, the 49ers?drafted?Louisiana State safety Eric Reid. The Cowboys took Wisconsin center Travis Frederick 31st.

The Falcons traded their first-round pick (No. 30) as well as third- and sixth-round choices (Nos. 92, 198) for?the Rams? first-round choice (No. 22 overall and formerly Washington?s Round One pick) and a conditional 2o15 seventh-round pick.?The Falcons drafted?Washington cornerback Desmond Trufant at No. 22. The Rams, meanwhile, selected Georgia linebacker Alec Ogletree at No. 30.

The Vikings, who had already exercised two earlier first-round picks (Nos. 23, 25), traded back into Round One, acquiring the Patriots? first-round pick (No. 29) in exchange for second-, third-, fourth- and seventh-round picks (Nos. 52, 83, 102, 229). (Pick No. 102 was originally Detroit?s selection.) The Vikings drafted?Tennessee wide receiver Cordarrelle Patterson at No. 29.

Source: http://profootballtalk.nbcsports.com/2013/04/25/e-j-manuel-is-the-first-quarterback-selected-by-the-buffalo-bills-with-16th-pick/related/

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Consumer sentiment wanes in April

NEW YORK (Reuters) - Consumer sentiment eased in April as Americans remained concerned about their employment and financial prospects, a survey released on Friday showed.

The Thomson Reuters/University of Michigan's final reading on the overall index on consumer sentiment fell to 76.4 from 78.6 in March, although it topped economists' expectations for 73.2.

It also was an improvement from April's preliminary reading of 72.3.

The barometer of current economic conditions fell to 89.9 from 90.7, while the gauge of consumer expectations slipped to 67.8 from 70.8.

Just 23 percent of consumers anticipated a decline in the unemployment rate during the coming year, while three out of four expected an unchanged or higher jobless rate.

Consumers continued to take a grim view of government economic policy, with just 9 percent rating policy favorably, slightly above the all-time low of 4 percent.

The outlook for vehicle and home purchases remained positive, with eight out of 10 respondents viewing home buying conditions as favorable. But the overall index measuring buying conditions for durable goods fell to 137 from 140.

The survey's one-year inflation expectation fell to 3.1 percent from 3.2 percent, while the survey's five-to-10-year inflation outlook also edged down to 2.9 percent from 2.8 percent.

(Reporting by Leah Schnurr)

Source: http://news.yahoo.com/consumer-sentiment-wanes-april-135843334.html

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Attaching files to Lists in SharePoint ? Business Management Daily ...

Most of us think Libraries for documents and Lists for data in SharePoint. However, you can actually attach files to list items.

Check the box to the left of the List item. On the Ribbon, choose the Items tab. In the Actions group, click the Attach File button, browse for and attach your file. To access the attachment, click the link to open the List item and look for the hyperlink to the attached file in the Attachments section of the form.

By default, lists allow for attachments. If the creator of the list has disallowed this feature, it won?t work.

Like what you've read? ...Republish it and share great business tips!

Attention: Readers, Publishers, Editors, Bloggers, Media, Webmasters and more...

We believe great content should be read and passed around. After all, knowledge IS power. And good business can become great with the right information at their fingertips. If you'd like to share any of the insightful articles on BusinessManagementDaily.com, you may republish or syndicate it without charge.

The only thing we ask is that you keep the article exactly as it was written and formatted. You also need to include an attribution statement and link to the article.

" This information is proudly provided by Business Management Daily.com: http://www.businessmanagementdaily.com/35161/attaching-files-to-lists-in-sharepoint "

Source: http://www.businessmanagementdaily.com/35161/attaching-files-to-lists-in-sharepoint

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This Panasonic HDTV Is Your Deal of the Day

TVs are more furniture-like than almost any other gadget. They're big, they find a spot in your living room, and they stay there for years. That's a major reason why smart functionality—that goes obsolete—baked into a TV is daft: who wants to replace a piece of furniture every other year? But Panasonic did just that, and now they've got a bunch of nice 47" LED IPS TV they want to clear out, because as the banner over the sale proclaims, "our new 2013 models have arrived!" More »

Source: http://feeds.gawker.com/~r/gizmodo/full/~3/rXe3ef_P3OU/this-panasonic-hdtv-is-your-deal-of-the-day

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Bahrain to hold 3rd Health and Wellness Expo | Ministry of ...

The event, organised by Bahrain Exhibition and Convention Authority with the huge support from Bahrain's Ministry of Industry & Commerce and Tamkeen (Labour Fund) as the strategic partner, aims to promote well-being and holistic lifestyle practices in day-to-day living and educate everyone to live a good and healthy life and provide a strategic platform for participating exhibitors including health professionals, specialists and other stakeholders for business-to-business meetings to achieve maximum exposure for their brands, gain networking opportunities, increased interest in health related products, generate new leads and increase revenue sources.

The Health & Wellness Expo this year offers a vast display of specially designed stage activities, health care products and services; free workshops and seminars concerning health; nutritional therapy; free medical check-up as well as try-out of fitness equipments; beauty treatments; live demos; and discounted memberships fees upon registration with fitness clubs.

The expo, covering 3,000 square meter event area in Hall 2 of the Exhibition Centre, will be open to the public with free admission from 10:00am until 7:00pm daily from 16th to 18th April 2013.

The Health & Wellness Expo has the mass support of the Ministry of Industry and Commerce, Ministry of Health, Tamkeen (Labour Fund) as the strategic partner, and Fitness First with media partners namely Bahrain Confidential Magazine, Gulf Insider Magazine, Areej Magazine, Communication Solutions and Insights, National Photo Services, National Images and Fakhri Travel and Tourism Centre.

Source: http://www.ameinfo.com/bahrain-hold-3rd-health-wellness-expo-337015

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LSUHSC research discovers new drug target for metastatic breast cancer

Public release date: 11-Apr-2013
[ | E-mail | Share ]

Contact: Leslie Capo
lcapo@lsuhsc.edu
504-568-4806
Louisiana State University Health Sciences Center

New Orleans, LA Research led by Dr. Suresh Alahari, Professor of Biochemistry and Molecular Biology at LSU Health Sciences Center New Orleans, is the first to report that two specific tumor suppressor genes work in concert to inhibit the growth and spread of breast tumor cells to the lungs. The research is published this week online in the Journal of Biological Chemistry.

Working in a mouse model, the LSUHSC research team studied LKB1, an enzyme that functions as a tumor suppressor in the small intestine, and Nischarin, a novel protein that regulates breast cancer cell migration and movement discovered by Dr. Alahari in 2000. Thirty percent of lung adenocarcinomas have an LKB1 gene mutation, and high levels of the LKB1 protein in breast cancer cells have been shown to significantly inhibit tumor growth. The LKB1-interacting protein is also structurally similar to Nischarin. The researchers suspected that the two suppressors might relate to each other, and they did in fact discover a functional and biochemical link between them.

The researchers demonstrated that Nischarin and LKB1 regulate breast cancer cell migration, anchorage-independent growth, tumor growth, and metastasis. They also identified a new pathway by which LKB1 suppresses tumor cell movement.

Metastasis, a complex process involving cell growth, tumor cell migration, and invasion is a leading cause of cancer-related deaths. Therefore, it is important to identify the molecular targets that can prevent cancer metastasis.

"The molecular mechanisms of tumor suppressor genes are not clearly understood, and each discovery moves us another step closer to a treatment advance or cure," notes Dr. Alahari.

Excluding skin cancer, breast cancer is the most common type of cancer among women in the United States. The American Cancer Society estimates 232,340 new cases of invasive breast cancer among American women this year, and 2,240 among men in the US, with 39,620 deaths in women and 410 deaths in men.

###

The LSUHSC team also included Prachi Jain, Somesh Baranwal, Shengli Dong, Amanda Struckhoff, and Rebecca Worthylake from the Departments of Biochemistry and Molecular Biology and Oral Biology.

The research was supported by grants from the National Institutes of Health, the Susan Komen Foundation, and the Louisiana Cancer Research Consortium.

LSU Health Sciences Center New Orleans educates Louisiana's health care professionals. The state's academic health leader, LSUHSC New Orleans consists of a School of Medicine, the only School of Dentistry in the state, Louisiana's only public School of Public Health, Schools of Allied Health Professions and Graduate Studies, and the only School of Nursing within an academic health center in the State of Louisiana. To learn more, visit http://www.lsuhsc.edu and http://www.twitter.com/LSUHSCHealth.

---

[ | E-mail | Share ]

?

AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.

Public release date: 11-Apr-2013
[ | E-mail | Share ]

Contact: Leslie Capo
lcapo@lsuhsc.edu
504-568-4806
Louisiana State University Health Sciences Center

New Orleans, LA Research led by Dr. Suresh Alahari, Professor of Biochemistry and Molecular Biology at LSU Health Sciences Center New Orleans, is the first to report that two specific tumor suppressor genes work in concert to inhibit the growth and spread of breast tumor cells to the lungs. The research is published this week online in the Journal of Biological Chemistry.

Working in a mouse model, the LSUHSC research team studied LKB1, an enzyme that functions as a tumor suppressor in the small intestine, and Nischarin, a novel protein that regulates breast cancer cell migration and movement discovered by Dr. Alahari in 2000. Thirty percent of lung adenocarcinomas have an LKB1 gene mutation, and high levels of the LKB1 protein in breast cancer cells have been shown to significantly inhibit tumor growth. The LKB1-interacting protein is also structurally similar to Nischarin. The researchers suspected that the two suppressors might relate to each other, and they did in fact discover a functional and biochemical link between them.

The researchers demonstrated that Nischarin and LKB1 regulate breast cancer cell migration, anchorage-independent growth, tumor growth, and metastasis. They also identified a new pathway by which LKB1 suppresses tumor cell movement.

Metastasis, a complex process involving cell growth, tumor cell migration, and invasion is a leading cause of cancer-related deaths. Therefore, it is important to identify the molecular targets that can prevent cancer metastasis.

"The molecular mechanisms of tumor suppressor genes are not clearly understood, and each discovery moves us another step closer to a treatment advance or cure," notes Dr. Alahari.

Excluding skin cancer, breast cancer is the most common type of cancer among women in the United States. The American Cancer Society estimates 232,340 new cases of invasive breast cancer among American women this year, and 2,240 among men in the US, with 39,620 deaths in women and 410 deaths in men.

###

The LSUHSC team also included Prachi Jain, Somesh Baranwal, Shengli Dong, Amanda Struckhoff, and Rebecca Worthylake from the Departments of Biochemistry and Molecular Biology and Oral Biology.

The research was supported by grants from the National Institutes of Health, the Susan Komen Foundation, and the Louisiana Cancer Research Consortium.

LSU Health Sciences Center New Orleans educates Louisiana's health care professionals. The state's academic health leader, LSUHSC New Orleans consists of a School of Medicine, the only School of Dentistry in the state, Louisiana's only public School of Public Health, Schools of Allied Health Professions and Graduate Studies, and the only School of Nursing within an academic health center in the State of Louisiana. To learn more, visit http://www.lsuhsc.edu and http://www.twitter.com/LSUHSCHealth.

---

[ | E-mail | Share ]

?

AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.

Source: http://www.eurekalert.org/pub_releases/2013-04/lsuh-lrd041113.php

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Transparent brain using hydrogel process

Apr. 10, 2013 ? Combining neuroscience and chemical engineering, researchers at Stanford University have developed a process that renders a mouse brain transparent. The postmortem brain remains whole -- not sliced or sectioned in any way -- with its three-dimensional complexity of fine wiring and molecular structures completely intact and able to be measured and probed at will with visible light and chemicals.

The process, called CLARITY, ushers in an entirely new era of whole-organ imaging that stands to fundamentally change our scientific understanding of the most-important-but-least-understood of organs, the brain, and potentially other organs, as well.

The process is described in a paper to be published online April 10 in Nature by bioengineer and psychiatrist Karl Deisseroth, MD, PhD, leading a multidisciplinary team, including postdoctoral scholar Kwanghun Chung, PhD.

"Studying intact systems with this sort of molecular resolution and global scope -- to be able to see the fine detail and the big picture at the same time -- has been a major unmet goal in biology, and a goal that CLARITY begins to address," Deisseroth said.

"This feat of chemical engineering promises to transform the way we study the brain's anatomy and how disease changes it," said Thomas Insel, MD, director of the National Institute of Mental Health. "No longer will the in-depth study of our most important three-dimensional organ be constrained by two-dimensional methods."

The research in this study was performed primarily on a mouse brain, but the researchers have used CLARITY on zebrafish and on preserved human brain samples with similar results, establishing a path for future studies of human samples and other organisms.

"CLARITY promises to revolutionize our understanding of how local and global changes in brain structure and activity translate into behavior," said Paul Frankland, PhD, a senior scientist in neurosciences and mental health at the Hospital for Sick Children Research Institute in Toronto, who was not involved in the research. Frankland's colleague, senior scientist Sheena Josselyn, PhD, added that the process could turn the brain from "a mysterious black box" into something essentially transparent.

An inscrutable place

The mound of convoluted grey matter and wiring that is the brain is a complex and inscrutable place. Neuroscientists have struggled to fully understand its circuitry in their quest to comprehend how the brain works, and why, sometimes, it doesn't.

CLARITY is the result of a research effort in Deisseroth's lab to extract the opaque elements -- in particular the lipids -- from a brain and yet keep the important features fully intact. Lipids are fatty molecules found throughout the brain and body. In the brain, especially, they help form cell membranes and give the brain much of its structure. Lipids pose a double challenge for biological study, however, because they make the brain largely impermeable both to chemicals and to light.

Neuroscientists would have liked to extract the lipids to reveal the brain's fine structure without slicing or sectioning, but for one major hitch: removing these structurally important molecules causes the remaining tissue to fall apart.

Prior investigations have focused instead on automating the slicing/sectioning approach, or in treating the brain with organic molecules that facilitate the penetration of light only, but not macromolecular probes. With CLARITY, Deisseroth's team has taken a fundamentally different approach.

"We drew upon chemical engineering to transform biological tissue into a new state that is intact but optically transparent and permeable to macromolecules," said Chung, the paper's first author.

This new form is created by replacing the brain's lipids with a hydrogel. The hydrogel is built from within the brain itself in a process conceptually similar to petrification, using what is initially a watery suspension of short, individual molecules known as hydrogel monomers. The intact, postmortem brain is immersed in the hydrogel solution and the monomers infuse the tissue. Then, when "thermally triggered," or heated slightly to about body temperature, the monomers begin to congeal into long molecular chains known as polymers, forming a mesh throughout the brain. This mesh holds everything together, but, importantly, it does not bind to the lipids.

With the tissue shored up in this way, the team is able to vigorously and rapidly extract lipids through a process called electrophoresis. What remains is a 3-D, transparent brain with all of its important structures -- neurons, axons, dendrites, synapses, proteins, nucleic acids and so forth -- intact and in place.

Going things one better

CLARITY then goes one better. In preserving the full continuity of neuronal structures, CLARITY not only allows tracing of individual neural connections over long distances through the brain, but also provides a way to gather rich, molecular information describing a cell's function is that is not possible with other methods.

"We thought that if we could remove the lipids nondestructively, we might be able to get both light and macromolecules to penetrate deep into tissue, allowing not only 3-D imaging, but also 3-D molecular analysis of the intact brain," said Deisseroth, who holds the D.H. Chen Professorship.

Using fluorescent antibodies that are known to seek out and attach themselves only to specific proteins, Deisseroth's team showed that it can target specific structures within the CLARITY-modified -- or "clarified" -- mouse brain and make those structures and only those structures light up under illumination. The researchers can trace neural circuits through the entire brain or explore deeply into the nuances of local circuit wiring. They can see the relationships between cells and investigate subcellular structures. They can even look at chemical relationships of protein complexes, nucleic acids and neurotransmitters.

"Being able to determine the molecular structure of various cells and their contacts through antibody staining is a core capability of CLARITY, separate from the optical transparency, which enables us to visualize relationships among brain components in fundamentally new ways," said Deisseroth, who is one of 15 experts on the "dream team" that will map out goals for the $100 million brain research initiative announced April 2 by President Obama.

And in yet another significant capability from a research standpoint, researchers are now able to destain the clarified brain, flushing out the fluorescent antibodies and repeating the staining process anew using different antibodies to explore different molecular targets in the same brain. This staining/destaining process can be repeated multiple times, the authors showed, and the different data sets aligned with one another.

Opening the door

CLARITY has accordingly made it possible to perform highly detailed, fine-structural analysis on intact brains -- even human tissues that have been preserved for many years, the team showed. Transforming human brains into transparent-but-stable specimens with accessible wiring and molecular detail may yield improved understanding of the structural underpinnings of brain function and disease.

Beyond the immediate and apparent benefit to neuroscience, Deisseroth cautioned that CLARITY has leapfrogged our ability to deal with the data. "Turning massive amounts of data into useful insight poses immense computational challenges that will have to be addressed. We will have to develop improved computational approaches to image segmentation, 3-D image registration, automated tracing and image acquisition," he said.

Indeed, such pressures will increase as CLARITY could begin to support a deeper understanding of large-scale intact biological systems and organs, perhaps even entire organisms.

"Of particular interest for future study are intrasystem relationships, not only in the mammalian brain but also in other tissues or diseases for which full understanding is only possible when thorough analysis of single, intact systems can be conducted," Deisseroth said. "CLARITY may be applicable to any biological system, and it will be interesting to see how other branches of biology may put it to use."

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Story Source:

The above story is reprinted from materials provided by Stanford University Medical Center. The original article was written by Andrew Myers.

Note: Materials may be edited for content and length. For further information, please contact the source cited above.

---

Journal Reference:

1. Kwanghun Chung, Jenelle Wallace, Sung-Yon Kim, Sandhiya Kalyanasundaram, Aaron S. Andalman, Thomas J. Davidson, Julie J. Mirzabekov, Kelly A. Zalocusky, Joanna Mattis, Aleksandra K. Denisin, Sally Pak, Hannah Bernstein, Charu Ramakrishnan, Logan Grosenick, Viviana Gradinaru, Karl Deisseroth. Structural and molecular interrogation of intact biological systems. Nature, 2013; DOI: 10.1038/nature12107

Note: If no author is given, the source is cited instead.

Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/top_news/top_science/~3/aprD_TDWLH8/130410131223.htm

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Will Ferrell's Comedic Genius Award? Thank Mark Wahlberg

'See what happens when you're in a movie with me?' Wahlberg jokes about Ferrell's upcoming honor at the MTV Movie Awards.
By Todd Gilchrist, with reporting by Josh Horowitz

Mark Wahlberg and Will Ferrell in "The Other Guys"
Photo: Sony Pictures

Source: http://www.mtv.com/news/articles/1705366/mark-wahlberg-will-ferrell-comedic-genius-award.jhtml

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Rosemary aroma may help you remember to do things

Apr. 9, 2013 ? The aroma of rosemary essential oil may improve prospective memory in healthy adults.

This is the finding of a study conducted by Jemma McCready and Dr Mark Moss from the University of Northumbria. The findings presented today, Tuesday 9 April, at the Annual Conference of the British Psychological Society in Harrogate, suggest that this essential oil may enhance the ability to remember events and to remember to complete tasks at particular times in the future.

Dr Mark Moss said: "We wanted to build on our previous research that indicated rosemary aroma improved long-term memory and mental arithmetic. In this study we focused on prospective memory, which involves the ability to remember events that will occur in the future and to remember to complete tasks at particular times this is critical for everyday functioning. For example when someone needs to remember to post a birthday card or to take medication at a particular time."

Rosemary essential oil was diffused in to a testing room by placing four drops on an aroma stream fan diffuser and switching this on five minutes before the participants entered the room. Sixty-six people took part in the study and were randomly allocated to either the rosemary-scented room or another room with no scent.

In each room participants completed a test designed to assess their prospective memory functions. This included tasks such as hiding objects and asking participants to find them at the end of the test and instructing them to pass a specified object to the researcher at a particular time. All the tasks had to be done with no prompting. If the task was not performed then different degrees of prompting were used. The more prompting that was used the lower the score. Participants also completed questionnaires assessing their mood.

Participants' blood was also analysed to see if performance levels and changes in mood following exposure to the rosemary aroma were related to concentrations of a compound (1,8-cineole) present in the blood. The compound is also found in the essential oil of rosemary and has previously been shown to act on the biochemical systems that underpin memory.

The results showed that participants in the rosemary-scented room performed better on the prospective memory tasks than the participants in the room with no scent. This was the case for remembering events and remembering to complete tasks at particular times.

Jemma McCready explained: "There was no link between the participants' mood and memory. This suggests performance is not influenced as a consequence of changes in alertness or arousal."

The results from the blood analysis found that significantly greater amounts of 1,8-cineole were present in the plasma of those in the rosemary scented room, suggesting that the influence of aroma was mediated pharmacologically.

Jemma McCready said: "These findings may have implications for treating individuals with memory impairments. It supports our previous research indicating that the aroma of rosemary essential oil can enhance cognitive functioning in healthy adults, here extending to the ability to remember events and to complete tasks in the future. Remembering when and where to go and for what reasons underpins everything we do, and we all suffer minor failings that can be frustrating and sometimes dangerous. Further research is needed to investigate if this treatment is useful for older adults who have experienced memory decline."

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Source: http://feeds.sciencedaily.com/~r/sciencedaily/top_news/top_health/~3/_CXFQl47q-g/130409091104.htm

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Kevin Gates' Luca Brasi Story Gets Retail Kiss Of Approval

Mafia mixtape gets an EP makeover, Gates tells Mixtape Daily.
By Rob Markman

Kevin Gates
Photo: MTV News

Source: http://www.mtv.com/news/articles/1705222/kevin-gates-luca-brasi-story.jhtml

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Kareem Abdul-Jabbar To Start Blood Cancer Research Fund

(CNS) Posted Tuesday, April 9 ? 9:43 AM

Kareem Abdul-Jabbar will launch a fundraising campaign for blood cancer research during halftime tonight, when the Los Angeles Lakers will meet the New Orleans Hornets at Staples Center.

Abdul-Jabbar will take to the court to start the countdown clock for the Chronic Myeloid Leukemia Skyhook Challenge to raise $38,387, matching the record number of points he scored in his NBA career. He was diagnosed with the disease in 2008.

Abdul-Jabbar will encourage fans to play the Skyhook Challenge via their mobile devices. By texting KAJ to 72645, participants will receive a series of questions about chronic myeloid leukemia, his career and the Leukemia Lymphoma Society. The game will also be available online at skyhookchallenge.com.

Each correct answer is worth one point. Once the challenge registers 38,387 points, the pharmaceutical maker Novartis will donate $38,387 to the Leukemia??Lymphoma Society to support blood cancer research and patient services. The contest will take place until the total fundraising goal is reached.

Donations can be made at lls.org/skyhookchallenge.

Since being diagnosed, Abdul-Jabbar has been a strong advocate for chronic myeloid leukemia patients, encouraging them to understand their treatment milestones and actively talk to their physicians to ensure their disease is properly managed.

Chronic myeloid leukemia is characterized by an abnormality known as the Philadelphia chromosome, which produces a protein called Bcr-Abl, identified as the sole cause and driver of the disease.

?Kareem?s message of hope is so inspirational and will help us bring more attention to the urgent need to fund research for breakthrough therapies, the only way we can achieve our goal of realizing a world without blood cancers,? said Lisa Stockmon, the society?s executive vice president and chief marketing officer.

Related Stories:

Source: http://bhcourier.com/kareem-abdul-jabbar-start-blood-cancer-research-fund/2013/04/09

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Cry me a river of possibility: Scientists design new adaptive material inspired by tears

Cry me a river of possibility: Scientists design new adaptive material inspired by tears

Monday, April 8, 2013

Imagine a tent that blocks light on a dry and sunny day, and becomes transparent and water-repellent on a dim, rainy day. Or highly precise, self-adjusting contact lenses that also clean themselves. Or pipelines that can optimize the rate of flow depending on the volume of fluid coming through them and the environmental conditions outside.

A team of researchers at the Wyss Institute at Harvard University and Harvard's School of Engineering and Applied Sciences (SEAS) just moved these enticing notions much closer to reality by designing a new kind of adaptive material with tunable transparency and wettability features, as reported yesterday in the online version of Nature Materials.

"The beauty of this system is that it's adaptive and multifunctional," said senior author Joanna Aizenberg, Ph.D., a Core Faculty member at the Wyss Institute and the Amy Smith Berylson Professor of Materials Science at SEAS.

The new material was inspired by dynamic, self-restoring systems in Nature, such as the liquid film that coats your eyes. Individual tears join up to form a dynamic liquid film with an obviously significant optical function that maintains clarity, while keeping the eye moist, protecting it against dust and bacteria, and helping to transport away any wastes ? doing all of this and more in literally the blink of an eye.

The bioinspired material is a continuous liquid film that coats, and is infused in, an elastic porous substrate ? which is what makes it so versatile. It is based on a core concept: any deformation of the substrate ? such as stretching, poking, or swelling - changes the size of the pores, which causes the liquid surface to change its shape.

With this design architecture in place, the team has thus far demonstrated the ability to dynamically control ? with great precision ? two key functions: transparency and wettability, said Xi Yao, Ph.D, Wyss Institute and SEAS postdoctoral fellow, and lead author of the study.

Sitting at rest, the material is smooth, clear and flat; droplets of water or oil on its surface flow freely off of the material. Stretching the material makes the fluid surface rougher, Yao explained. The rough surface makes it opaque for one thing, and enables one to do something never possible before: It offers the ability to make every droplet of oil or water that is placed on it reversibly start and stop in their tracks. This capability is far superior to the "switchable wettability" of other adaptive materials that exist today, Yao said, which simply switch between two states ? from hydrophobic (water-hating) to hydrophilic (water-loving).

"In addition to transparency and wettability, we can fine-tune basically anything that would respond to a change in surface topography, such as adhesive or anti-fouling behavior," Yao said. They can also design the porous elastic solid such that it responds dynamically to temperature, light, magnetic or electric fields, chemical signals, pressure, or other environmental conditions, he said.

The material is a next generation of a materials platform that Aizenberg pioneered a few years ago called SLIPS. SLIPS stands for Slippery Liquid-Infused Porous Surfaces, and is a coating that repels just about anything with which it comes into contact ? from oil to water and blood.

But whereas SLIPS is a liquid-infused rigid porous surface, "the new material is a liquid-infused elastic porous surface, which is what allows for the fine control over so many adaptive responses above and beyond its ability to repel a wide range of substances. A whole range of surface properties can now be tuned, or switched on and off on demand, through stimulus-induced deformation of the elastic material," Aizenberg said.

"This sophisticated new class of adaptive materials being designed by the Institute's Adaptive Materials Technologies platform led by Joanna Aizenberg have the potential to be game-changers in everything from oil and gas pipelines, to microfluidic and optical systems, building design and construction, textiles, and more," said Wyss Founding Director Donald Ingber, M.D., Ph.D.

###

Wyss Institute for Biologically Inspired Engineering at Harvard: http://wyss.harvard.edu/

Thanks to Wyss Institute for Biologically Inspired Engineering at Harvard for this article.

This press release was posted to serve as a topic for discussion. Please comment below. We try our best to only post press releases that are associated with peer reviewed scientific literature. Critical discussions of the research are appreciated. If you need help finding a link to the original article, please contact us on twitter or via e-mail.

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Source: http://www.labspaces.net/127630/Cry_me_a_river_of_possibility__Scientists_design_new_adaptive_material_inspired_by_tears

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It's official: Sanford facing Colbert Busch in SC

Former South Carolina Gov. Mark Sanford thanks his fiance Maria Belen Chapur as he addresses supporters in Mount Pleasant, S.C., on Tuesday, April 2, 2013, after winning the GOP nomination for the U.S. House seat he once held. Sanford is trying to make a comeback after his political career was derailed four years ago when he disappeared from the state only to return to admit the couple was having an affair. Sanford's wife, Jenny, later divorced him. (AP Photo/Bruce Smith)

Former South Carolina Gov. Mark Sanford thanks his fiance Maria Belen Chapur as he addresses supporters in Mount Pleasant, S.C., on Tuesday, April 2, 2013, after winning the GOP nomination for the U.S. House seat he once held. Sanford is trying to make a comeback after his political career was derailed four years ago when he disappeared from the state only to return to admit the couple was having an affair. Sanford's wife, Jenny, later divorced him. (AP Photo/Bruce Smith)

MOUNT PLEASANT, S.C. (AP) ? The race for a vacant South Carolina congressional seat has turned into the big-name contest that political junkies were hoping for.

Former South Carolina Gov. Mark Sanford, a Republican trying to make a comeback after his political career was derailed by his admission of an extramarital affair, faces Democrat Elizabeth Colbert Busch, the sister of political satirist Stephen Colbert, in a May 7 special election.

Sanford defeated former Charleston County Councilman Curtis Bostic in the GOP primary runoff Tuesday, clearing another hurdle in his quest for political redemption. He finished first last month in a 16-candidate field in the primary in the state's 1st Congressional District, which runs northeast along the coast from Hilton Head Island through Charleston and to the Georgetown County line.

Colbert Busch ? who once worked in Washington as an intern for then-U.S. Senator Ernest "Fritz" Hollings, D-S.C. ? has had a lifelong dream of running for public office. The businesswoman has said jobs is a top priority for her campaign. Colbert Busch has worked in the shipping industry for years and is now on a leave of absence from her position as the director of business development for Clemson University's Wind Turbine Drive Testing Facility.

Last month, she easily defeated perennial candidate Ben Frasier to win the Democratic nomination in the Republican-leaning district.

"We need a voice in Washington who stands up for South Carolina solutions - not either political party. And my business experience will get the job done," Colbert Busch said in a statement after Sanford won.

Sanford on Tuesday collected about 57 percent of the vote in defeating Bostic.

"It's been a very long journey. And in that journey I am humbled to find ourselves where we find ourselves tonight," the 52-year-old Sanford said.

In 2009, Sanford, in his second term as governor, was a rising Republican political star before he vanished from South Carolina for five days. Reporters were told he was hiking the Appalachian Trail, but he later tearfully acknowledged he had been visiting Maria Belen Chapur, which he told everyone at a news conference announcing an extramarital affair. He later called her his soul mate.

Before leaving office as governor, Sanford avoided impeachment but was censured by the Legislature over state travel expenses he used for the affair. He also had to pay more than $70,000 in ethics fines ? still the largest in state history ? after Associated Press investigations raised questions about his use of state, private and commercial aircraft.

Sanford's wife Jenny later divorced him and wrote a book, and Sanford and his former mistress are now engaged. She appeared at Sanford's side during his victory speech but did not address the crowd.

"I want to thank my God," Sanford said. "I used to cringe when somebody would say, 'I want to thank my God,' because at that point I would think this is getting uncomfortable. But once you really receive God's grace and (have) seen it reflected in others you stop and acknowledge that grace and the difference he has made in my life and in so many lives across this state and across this nation."

The 1st District seat became open when Republican Tim Scott was appointed to fill the remaining two years of U.S. Sen. Jim DeMint's term. DeMint resigned to head The Heritage Foundation, a conservative think tank.

Sanford has been stressing his credentials as a fiscal conservative who would help get the nation's finances in order.

Bostic had argued that Sanford's indiscretions had left him a compromised candidate, leaving the door open for the Democrats to capture a seat in Congress they have not held in more than 30 years.

"I believe this race is more than a story of Mark's redemption," Bostic said while visiting a polling place Tuesday. "It's more than a story of my hopes and aspirations. I think it's about keeping conservative values alive and well."

But it has also proved a story of Sanford's redemption.

Sanford, who held the 1st Congressional District seat for three terms before he was elected governor, said earlier Tuesday the runoff results would give a good indication whether voters have moved past his personal indiscretions.

When asked later if they had, he replied simply "I'm both humbled and grateful for the response of the voters."

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/386c25518f464186bf7a2ac026580ce7/Article_2013-04-03-1st%20District-South%20Carolina/id-b1332393627c4dcbb88a5bf442b99f6a

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